A Multimodal Interventions for Managing Chronic Pain in Older Adults: A Randomized Controlled Trial in Primary Health Care Settings.
DOI:
https://doi.org/10.70860_abef20253344Abstract
Chronic musculoskeletal pain (CMSP) is a prevalent condition among older adults, which can significantly reduce functional capacity and quality of life. Multimodal interventions (MIs), combining aerobic, resistance, and balance exercises, are promising but understudied in primary healthcare settings. Objective: To evaluate the effectiveness of a 12-week MI program in reducing pain intensity and improving functional outcomes in older adults with CMSP. Methods: A randomized controlled trial was conducted with 113 participants (mean age: 68.5 ± 5.3 years), randomly assigned to an experimental group (EG, n=57) or control group (CG, n=56). Pain intensity (Numeric Rating Scale), functional capacity (6-minute walk test; 6MWT), and lower-limb strength (30-second sit-to-stand test; 30 s-CST) were assessed at baseline and post-intervention. Data were analyzed using repeated-measures ANOVA, with effect sizes calculated for clinical relevance. Results: Pain intensity decreased by 2.53 points (95% CI: 2.34–2.72) in the EG, surpassing the MCID threshold of 1–2 points (p<0.0001). Functional capacity improved by 23.87 meters (95% CI: 5.27–42.47) in the 6MWT, exceeding the MCID range of 14–30 meters (p<0.0001). Lower-limb strength increased by 0.89 repetitions (95% CI: 0.15–1.26) in the 30 s-CST, representing meaningful progress despite falling short of the MCID threshold of 2 repetitions. Effect sizes were moderate to large for all outcomes. Conclusion: The multimodal intervention significantly reduced pain and enhanced functional capacity, demonstrating its clinical impact and practical utility for managing CMSP. Further research should assess the long-term impacts of MIs and explore implementation in diverse settings.
References
Adogwa, O., Reid, M. C., Chilakapati, S., & Makris, U. E. (2023). CLIN‐STAR corner: 2021 update in musculoskeletal pain in older adults with a focus on osteoarthritis‐related pain. Journal of the American Geriatrics Society, 71(8), 2373–2380. https://doi.org/10.1111/jgs.18369.
Agarwala, P., & Salzman, S. H. (2020). Six-Minute Walk Test: Clinical Role, Technique, Coding, and Reimbursement. Chest, 157(3), 603–611. https://doi.org/10.1016/j.chest.2019.10.014
Baker, M. K., Atlantis, E., & Fiatarone Singh, M. A. (2007). Multi-modal exercise programs for older adults. Age and Ageing, 36(4), 375–381. https://doi.org/10.1093/ageing/afm054
Barisch-Fritz, B., Trautwein, S., Scharpf, A., Krell-Roesch, J., & Woll, A. (2022). Effects of a 16-Week Multimodal Exercise Program on Physical Performance in Individuals With Dementia: A Multicenter Randomized Controlled Trial. Journal of Geriatric Physical Therapy, 45(1), 3–24. https://doi.org/10.1519/JPT.0000000000000308
Bohannon, R. W., & Crouch, R. (2017). Minimal clinically important difference for change in 6‐minute walk test distance of adults with pathology: A systematic review. Journal of Evaluation in Clinical Practice, 23(2), 377–381. https://doi.org/10.1111/jep.12629
Chen, J., Wang, X., & Xu, Z. (2023). Sarcopenia and Chronic Pain in the Elderly: A Systematic Review and Meta-Analysis. Journal of Pain Research, Volume 16, 3569–3581. https://doi.org/10.2147/JPR.S435866
Colado, J. C., Pedrosa, F. M., Juesas, A., Gargallo, P., Carrasco, J. J., Flandez, J., … Naclerio, F. (2018). Concurrent validation of the OMNI-Resistance Exercise Scale of perceived exertion with elastic bands in the elderly. Experimental Gerontology, 103, 11–16. https://doi.org/10.1016/j.exger.2017.12.009
Derry, S., Conaghan, P., Da Silva, J. A. P., Wiffen, P. J., & Moore, R. A. (2016). Topical NSAIDs for chronic musculoskeletal pain in adults. Cochrane Database of Systematic Reviews, 2020(2). https://doi.org/10.1002/14651858.CD007400.pub3
Domingues, L., & Cruz, E. ([s.d.]). Adaptação Cultural e Contributo para a Validação da Escala. 2.
Efird, J. (2010). Blocked Randomization with Randomly Selected Block Sizes. International Journal of Environmental Research and Public Health, 8(1), 15–20. https://doi.org/10.3390/ijerph8010015
Farrar, J. T., Young, J. P., LaMoreaux, L., Werth, J. L., & Poole, M. R. (2001). Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain, 94(2), 149–158. https://doi.org/10.1016/S0304-3959(01)00349-9
Honorato Dos Santos De Carvalho, V. C., Rossato, S. L., Fuchs, F. D., Harzheim, E., & Fuchs, S. C. (2013). Assessment of primary health care received by the elderly and health related quality of life: A cross-sectional study. BMC Public Health, 13(1), 605. https://doi.org/10.1186/1471-2458-13-605
Jones, C. J., Rikli, R. E., & Beam, W. C. (1999). A 30-s Chair-Stand Test as a Measure of Lower Body Strength in Community-Residing Older Adults. Research Quarterly for Exercise and Sport, 70(2), 113–119. https://doi.org/10.1080/02701367.1999.10608028
Kechichian, A., Lafrance, S., Matifat, E., Dubé, F., Lussier, D., Benhaim, P., … Desmeules, F. (2022). Multimodal Interventions Including Rehabilitation Exercise for Older Adults With Chronic Musculoskeletal Pain: A Systematic Review and Meta-analyses of Randomized Controlled Trials. Journal of Geriatric Physical Therapy, 45(1), 34–49. https://doi.org/10.1519/JPT.0000000000000279
McCoy, C. E. (2017). Understanding the Intention-to-treat Principle in Randomized Controlled Trials. The Western Journal of Emergency Medicine, 18(6), 1075–1078. https://doi.org/10.5811/westjem.2017.8.35985
McEwen, V., Esterlis, M. M., Lorello, R. G., Sud, A., Englesakis, F. M., & Bhatia, A. (2023). A Scoping Review of Gaps Identified by Primary Care Providers in Caring for Patients with Chronic Noncancer Pain. Canadian Journal of Pain = Revue Canadienne De La Douleur, 7(1), 2145940. https://doi.org/10.1080/24740527.2022.2145940
Melo, D. M. D., & Barbosa, A. J. G. (2015). O uso do Mini-Exame do Estado Mental em pesquisas com idosos no Brasil: Uma revisão sistemática. Ciência & Saúde Coletiva, 20(12), 3865–3876. https://doi.org/10.1590/1413-812320152012.06032015 .
Merkow, R. P., Kaji, A. H., & Itani, K. M. F. (2021). The CONSORT Framework. JAMA Surgery, 156(9), 877. https://doi.org/10.1001/jamasurg.2021.0549
Mikkelsen, M. K., Lund, C. M., Vinther, A., Tolver, A., Johansen, J. S., Chen, I., … Jarden, M. (2022). Effects of a 12-Week Multimodal Exercise Intervention Among Older Patients with Advanced Cancer: Results from a Randomized Controlled Trial. The Oncologist, 27(1), 67–78. https://doi.org/10.1002/onco.13970
Morcillo-Muñoz, Y., Castellano, M. H. J., Exposito, F. J. D., Sanchez-Guarnido, A. J., Alcantara, M. G., & Baena-Parejo, M. I. (2021). Multimodal Interventions to Improve the Management of Chronic Non-Malignant Pain in Primary Care Using Participatory Research. Clinics and Practice, 11(3), 561–581. https://doi.org/10.3390/clinpract11030072
Neil-Sztramko, S. E., Teggart, K., Moore, C., Sherifali, D., Fitzpatrick-Lewis, D., Coletta, G., … Ganann, R. (2022). Community-based group physical activity and/or nutrition interventions to promote mobility in older adults: An umbrella review. BMC Geriatrics, 22(1), 539. https://doi.org/10.1186/s12877-022-03170-9
Olsen, M. F., Bjerre, E., Hansen, M. D., Tendal, B., Hilden, J., & Hróbjartsson, A. (2018). Minimum clinically important differences in chronic pain vary considerably by baseline pain and methodological factors: Systematic review of empirical studies. Journal of Clinical Epidemiology, 101, 87-106.e2. https://doi.org/10.1016/j.jclinepi.2018.05.007
Poolman, R. W., Struijs, P. A. A., Krips, R., Sierevelt, I. N., Marti, R. K., Farrokhyar, F., & Bhandari, M. (2007). Reporting of Outcomes in Orthopaedic Randomized Trials: Does Blinding of Outcome Assessors Matter? The Journal of Bone & Joint Surgery, 89(3), 550–558. https://doi.org/10.2106/JBJS.F.00683
Reid, M. C., Eccleston, C., & Pillemer, K. (2015). Management of chronic pain in older adults. BMJ (Clinical Research Ed.), 350, h532. https://doi.org/10.1136/bmj.h532
Rice, D., Nijs, J., Kosek, E., Wideman, T., Hasenbring, M. I., Koltyn, K., … Polli, A. (2019). Exercise-Induced Hypoalgesia in Pain-Free and Chronic Pain Populations: State of the Art and Future Directions. The Journal of Pain, 20(11), 1249–1266. https://doi.org/10.1016/j.jpain.2019.03.005
Salaffi, F., Stancati, A., Silvestri, C. A.,
Ciapetti, A., & Grassi, W. (2004). Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale. European Journal of Pain, 8(4), 283–291. https://doi.org/10.1016/j.ejpain.2003.09.004
Santiago-Bravo, G., Sudo, F. K., Assunção, N., Drummond, C., & Mattos, P. (2019). Dementia screening in Brazil: A systematic review of normative data for the mini-mental state examination. Clinics, 74, e971. https://doi.org/10.6061/clinics/2019/e971
Schwan, J., Sclafani, J., & Tawfik, V. L. (2019). Chronic Pain Management in the Elderly. Anesthesiology Clinics, 37(3), 547–560. https://doi.org/10.1016/j.anclin.2019.04.012
Sluka, K. A., Frey-Law, L., & Hoeger Bement, M. (2018). Exercise-induced pain and analgesia? Underlying mechanisms and clinical translation. Pain, 159(1), S91–S97. https://doi.org/10.1097/j.pain.0000000000001235
Torres, J. L., Da Silva, S. L. A., Ferreira, F. R., Mendes, L. P. S., & Machado, L. A. (2019). Chronic pain is associated with increased health care use among community-dwelling older adults in Brazil: The Pain in the Elderly (PAINEL) Study. Family Practice, 36(5), 594–599. https://doi.org/10.1093/fampra/cmy123.
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